The Xia Reasearch Group

Research

Interfacial Behaviors of Biomolecules and Biosensors

        Millions of bioreactions take place on the cell-membrane interface which regulate and control the behaviors of the cells, tissues, even the activities of the organisms. Here we focus our interests on biomolecular behaviors on bionic artificial interfaces and try to explain the similar progresses happening in vivo. 

Effect of Interfacial Micro-Enviroment on Elelctron Transfer and Biosensing

        Most bioreactions and biomolecule transfers occur at biointerfaces. The development of a biosensing device also need an interface to transfer chemical/biological information into optical/electrical signal. Therefore, understanding the behavoir of biomolecules at interfaces are fundamentally important. Interfacial micro-enviroment, including pH, distance between biomolecules and an electrode, hydrophilic/hydrophobic properties, charge, electrode potential, orentation of molecuels, are essential for the development of biosensing devices.

       Our group are interested in building biointerfaces with different micro-enviroments (or tunable micro-enviroments) and explore the effect of above mentioned micro-enviromental factors on the optical and electrochemical behavoir of biomolecu
les. (Chem. Commun., 2015,51, 689;Chemical Communications 2012, 48 (88): 10859 - 10861. Figure 1; Chem. Commun., 2013,49, 8788 Figure 2) 

 

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Figure 1. Hemin at gold-water interface with different conformation


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 Figure 2. Monitoring of protein kinase activity and inhibition