The Xia Reasearch Group

2015

251.Fluorescent Sulfur-tagged Europium (III) Coordination Polymers for Monitoring Reactive Oxygen Species

ABSTRACT: Oxidative  stress caused by reactive oxygen species (ROS) is harmful to biological  systems and implicated in various diseases. A variety of selective  fluorescent probes have been developed for detecting ROS to uncover  their biological functions. Generally, the preparation of the  fluorescent probes usually undergoes multiple synthetic steps, and the  successful fluorescent sensing usually relies on trial-and-error tests.  Herein we present a simple way to prepare fluorescent ROS probes that  can be used both in biological and environmental systems. The  fluorescent europium (III) coordination polymers (CPs) are prepared by  simply mixing the precursors [2,2′-Thiodiacetic acid and Eu(NO3)3·6H2O]  in ethanol. Interestingly, with the increase of reaction temperature,  the product undergoes a morphological transformation from microcrystal  to nanoparticle while the structure and fluorescent properties retain.  The fluorescence of the sulfur-tagged europium (III) CPs can be  selectively quenched by ROS and thus sensitive and selective monitoring  of ROS in aerosols by the microcrystals and in live cells by the  nanoparticles has been achieved. The results reveal that the  sulfur-tagged europium (III) CPs provide a novel sensor for imaging ROS  in biological and environmental systems.

 

DOI:10.1021/acs.analchem.5b01104