Congratulations to Dr. Huaisong Wang's paper published on NPG Asia Materials
Abstract:Two-dimensional (2D) materials have attracted tremendous interest as ﬂuorescence quenchers of dye-labeled biomolecules for application in biosensing. Metal-organic framework (MOF) nanosheets, as a new type of 2D material, have rarely been studied as bioanalytical platforms. Herein, we synthesize a series of ultrathin lanthanide-based MOF (MOF-Ln) nanosheets as a dye-labeled aptamer platform. The ﬂuorescence quenching or recovery on the MOF-Ln nanosheets is determined by the charge properties (positive or negative) of the labeled ﬂuorophores. The negatively charged ﬂuorophores experience a ﬂuorescence ‘turn-down followed by turn-down’ process, whereas the positively charged ﬂuorophores experience a ﬂuorescence ‘turn-down followed by turn-up’ process. The interesting ﬂuorescence quenching properties of the MOF-Ln nanosheets make them an excellent two-color sensing platform for the intracellular detection of biomolecules.