The Xia Reasearch Group

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Congratulations to Dr. Jun Ouyang's paper accepted by Adv. Funct. Mater.. on Aug 20

 Congratulations to Dr. Jun Ouyang's paper accepted by Adv. Funct. Mater.. on Aug 20

Abstract: We propose a strategy to achieve enhanced capture efficiency of and low damage to CCRF-CEM captured by the synergistic effect of topographical interactions and phenylboronic acid functional group on the nanostructures. To realize this purpose, a simple and template free method to synthesize boronic acid derivative polyaniline (PANI) bioinspired nanostructures with controlled morphology is established. Different nanostructured morphologies such as nanotexture, nanofibers, nanoparticles, microsphere, and 3D porous network have been prepared by controlling the nucleation and growth rate for polymerization. The phenylboronic acid functional groups on the surface of the nanostructures during polymerization are used as the artificial lectins to reversibly capture and release circulating tumor cells (CTCs) with little damage to the cells. The method presented here is simple, rapid, and highly efficient for CTCs capture and release with low cost in materials and instruments.